{"id":10861,"date":"2020-06-26T09:24:11","date_gmt":"2020-06-26T06:24:11","guid":{"rendered":"https:\/\/umram.bilkent.edu.tr\/?p=10861"},"modified":"2020-06-26T09:24:11","modified_gmt":"2020-06-26T06:24:11","slug":"in-vivo-human-head-mri-at-10-5t-a-radiofrequency-safety-study-and-preliminary-imaging-results","status":"publish","type":"post","link":"https:\/\/umram.bilkent.edu.tr\/index.php\/2020\/06\/26\/in-vivo-human-head-mri-at-10-5t-a-radiofrequency-safety-study-and-preliminary-imaging-results\/","title":{"rendered":"In vivo human head MRI at 10.5T: A radiofrequency safety study and preliminary imaging results"},"content":{"rendered":"<section class=\"kc-elm kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-971711 kc_text_block\"><p>A collaborative work between CMRR and UMRAM resulted in a manuscript&nbsp;entitled&nbsp;\u201c<em>In vivo human head MRI at 10.5T: A radiofrequency safety study and preliminary imaging results.<\/em>\u201d In this study, the first human brain images obtained from a 10.5T system are shown. 10.5T is currently the highest field strength&nbsp;full-body imaging system in the world and housed at CMRR in the University of Minnesota. The first author of the paper is&nbsp;<strong><a href=\"https:\/\/umram.bilkent.edu.tr\/index.php\/teams\/alireza-sadeghi-tarakameh\/\">Alireza Sadeghi\u2010Tarakameh<\/a>&nbsp;<\/strong>who is a PhD student of&nbsp;<strong><a href=\"https:\/\/umram.bilkent.edu.tr\/index.php\/teams\/ergin-atalar\/\">Ergin Atalar<\/a>.&nbsp;<\/strong>&nbsp;The senior author of the article,<strong>&nbsp;<\/strong><a href=\"https:\/\/umram.bilkent.edu.tr\/index.php\/teams\/yigitcan-eryaman\/\"><strong>Yi\u011fitcan Eryaman<\/strong><\/a>&nbsp;is an assistant professor at CMRR and received his PhD degree from Bilkent University. The other authors of the paper are&nbsp;Lance DelaBarre, Russell L. Lagore, Angel Torrado-Carvajal, Xiaoping Wu, Andrea Grant, Gregor Adriany, Gregory J. Metzger, Pierre-Francois Van de Moortele, and Kamil Ugurbil of CMRR.<\/p>\n<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>Purpose<\/p>\n<p>The purpose of this study is to safely acquire the first human head images at 10.5 T.<\/p>\n<p>Methods<\/p>\n<p>In order to ensure safety of subjects, we validated the electromagnetic (EM) simulation model of our coil. We obtained quantitative agreement between simulated and experimental B<sub>1<\/sub><sup>+<\/sup> and specific absorption rate (SAR). Using the validated coil model, we calculated radiofrequency (RF) power levels to safely image human subjects. We conducted all experiments and imaging sessions in a controlled RF safety lab and the whole-body 10.5T scanner in the Center for Magnetic Resonance Research (CMRR).<\/p>\n<p>Results<\/p>\n<p>Quantitative agreement between the simulated and experimental results was obtained including S-parameters, B<sub>1<\/sub><sup>+<\/sup> maps, and SAR. We calculated peak 10 g average SAR using four different realistic human body models for a quadrature excitation and demonstrated that the peak 10 g SAR variation between subjects was less than 30%. We calculated safe power limits based on this set and used those limits to acquire T2- and T2<sup>*<\/sup>-weighted images of human subjects at 10.5 T.<\/p>\n<p>Conclusion<\/p>\n<p>In this study, we acquired the first in vivo human head images at 10.5 T using an eight-channel transmit\/receive (Tx\/Rx) coil. We implemented and expanded a previously proposed workflow to validate the EM simulation model of the eight-channel Tx\/Rx coil. Using the validated coil model, we calculated RF power levels to safely image human subjects.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":7,"featured_media":10863,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[256],"tags":[],"_links":{"self":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/10861"}],"collection":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/comments?post=10861"}],"version-history":[{"count":2,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/10861\/revisions"}],"predecessor-version":[{"id":10865,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/10861\/revisions\/10865"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/media\/10863"}],"wp:attachment":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/media?parent=10861"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/categories?post=10861"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/tags?post=10861"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}