{"id":12318,"date":"2024-03-05T10:27:40","date_gmt":"2024-03-05T07:27:40","guid":{"rendered":"https:\/\/umram.bilkent.edu.tr\/?p=12318"},"modified":"2024-03-05T10:27:40","modified_gmt":"2024-03-05T07:27:40","slug":"umram-nsc-asbam-guz-2023-seminerleri-processing-and-representation-of-decision-variables-across-interacting-brain-regions-in-a-complex-spatial-task","status":"publish","type":"post","link":"https:\/\/umram.bilkent.edu.tr\/index.php\/tr\/2024\/03\/05\/umram-nsc-asbam-guz-2023-seminerleri-processing-and-representation-of-decision-variables-across-interacting-brain-regions-in-a-complex-spatial-task\/","title":{"rendered":"UMRAM\/NSC-ASBAM G\u00fcz 2023 Seminerleri:  &#8221;Processing and representation of decision variables across interacting brain regions in a complex spatial task &#8221;"},"content":{"rendered":"<p><strong>U\u011furcan Mugan<\/strong><\/p>\n<p><strong>Tarih:<\/strong>\u00a025 Ekim 2023<\/p>\n<p><strong>Saat:<\/strong> 12.30-13.30<\/p>\n<p><strong>Yer:<\/strong> Seminer Odas\u0131, SC 106<\/p>\n<p>&nbsp;<\/p>\n<p>Do\u011fal ortamlardaki kararlar dinamik, zamansal olarak geni\u015fletilmi\u015f ve topolojik olarak karma\u015f\u0131k ortamlarda ger\u00e7ekle\u015fir. Karar vermenin sinirsel ve davran\u0131\u015fsal ba\u011f\u0131nt\u0131lar\u0131 \u00fczerine yap\u0131lan geni\u015f bir ara\u015ft\u0131rma yelpazesi, beynin farkl\u0131 durumlar ve ba\u011flamlar i\u00e7in uyarlanabilir stratejiler \u00fcretmek i\u00e7in birden fazla rekabet eden sistem i\u00e7erdi\u011fini g\u00f6stermektedir. Bu iki soruyu g\u00fcndeme getiriyor:<\/p>\n<p>1) farkl\u0131 sinir devreleri yap\u0131sal olarak farkl\u0131 ortamlar\u0131 nas\u0131l temsil eder ve<\/p>\n<p>2) farkl\u0131 karma\u015f\u0131k ortamlarda uyarlanabilir davran\u0131\u015flar\u0131 te\u015fvik etmek i\u00e7in beyin b\u00f6lgeleri aras\u0131ndaki etkile\u015fimler nas\u0131l de\u011fi\u015fir?<\/p>\n<p>Serbest\u00e7e davranan sol\/sa\u011f\/alternatif yiyecek arama s\u0131ras\u0131nda kemirgenin medial prefrontal korteksinden, hipokampusundan ve dorsolateral striatumundan (s\u0131ras\u0131yla bilin\u00e7li ve prosed\u00fcrel olmak \u00fczere farkl\u0131 karar verme paradigmalar\u0131nda yer alan t\u00fcm b\u00f6lgeler) e\u015f zamanl\u0131 kay\u0131t yaparak bu sorular\u0131 yan\u0131tlamaya \u00e7al\u0131\u015ft\u0131k. g\u00f6rev. Ayr\u0131ca, \u00fcst d\u00fczey strateji belirlemede merkez olarak medial prefrontal korteksin rol\u00fcn\u00fc izole etmek i\u00e7in dorsal prefrontal korteksi kemogenetik olarak inhibe ettik. \u00c7al\u0131\u015fmam\u0131z, bilin\u00e7li ve al\u0131\u015f\u0131lm\u0131\u015f karar vermenin, hayvan\u0131n i\u00e7inde bulundu\u011fu \u00e7evre taraf\u0131ndan b\u00fcy\u00fck \u00f6l\u00e7\u00fcde mod\u00fcle edildi\u011fini, daha karma\u015f\u0131k ortamlar\u0131n (prefrontal-hipokampal etkile\u015fimler yoluyla) daha uzun m\u00fczakere d\u00f6nemleri ve daha ayr\u0131nt\u0131l\u0131 \u00e7evresel temsiller gerektirdi\u011fini \u00f6ne s\u00fcr\u00fcyor. Dahas\u0131, prosed\u00fcrel karar vermeyle ili\u015fkili sinirsel imzalar, \u00e7evre topolojisinin hedef ve alt hedef temsillerini etkiledi\u011fini ileri s\u00fcrerek, karar almay\u0131 hiyerar\u015fik bir s\u00fcre\u00e7 olarak modelleme fikrini daha da g\u00fc\u00e7lendiriyor. Bu bulgular birlikte, birbirine ba\u011fl\u0131 beyin b\u00f6lgeleri aras\u0131ndaki aktivitenin ve etkile\u015fimlerin, farkl\u0131 g\u00f6rev karma\u015f\u0131kl\u0131\u011f\u0131 seviyelerindeki hesaplama taleplerini nas\u0131l kar\u015f\u0131lad\u0131\u011f\u0131n\u0131 a\u00e7\u0131klamay\u0131 ama\u00e7lamaktad\u0131r.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Biyografi:<\/strong><\/p>\n<p>U\u011furcan Mugan, Minnesota \u00dcniversitesi sinir bilimi b\u00f6l\u00fcm\u00fcnde Dr. David Redish ile birlikte \u00e7al\u0131\u015fan doktora sonras\u0131 ara\u015ft\u0131rmac\u0131d\u0131r. Lisans e\u011fitimini Bilkent \u00dcniversitesi Elektrik ve Elektronik M\u00fchendisli\u011fi b\u00f6l\u00fcm\u00fcnde tamamlad\u0131 ve ard\u0131ndan Northwestern \u00dcniversitesi&#8217;nde hesaplamal\u0131 ve evrimsel sinirbilim odakl\u0131 Biyomedikal M\u00fchendisli\u011fi alan\u0131nda doktora yapt\u0131. Doktora sonras\u0131 \u00e7al\u0131\u015fmas\u0131nda, \u00f6zg\u00fcrce davranan hayvanlarda elektrofizyoloji ve kemogenetik kullanarak birbirine ba\u011fl\u0131 beyin b\u00f6lgelerinde karar de\u011fi\u015fkenlerinin temsillerinin g\u00f6rev talepleriyle nas\u0131l de\u011fi\u015fti\u011fini inceledi. \u015eu anda, elektrofizyoloji ve \u00e7ift renkli optogenetik kullanarak de\u011fi\u015fken karma\u015f\u0131kl\u0131kta bir mekansal \u00e7al\u0131\u015fma haf\u0131zas\u0131 g\u00f6revinde, prefrontal korteks ve hipokampus aras\u0131ndaki bilgi aktar\u0131m\u0131nda genetik olarak farkl\u0131 n\u00f6ron t\u00fcrlerinin katk\u0131lar\u0131na bak\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>U\u011furcan Mugan Tarih:\u00a025 Ekim 2023 Saat: 12.30-13.30 Yer: Seminer Odas\u0131, SC 106 &nbsp; Do\u011fal ortamlardaki kararlar dinamik, zamansal olarak geni\u015fletilmi\u015f ve topolojik olarak karma\u015f\u0131k ortamlarda ger\u00e7ekle\u015fir. Karar vermenin sinirsel ve davran\u0131\u015fsal ba\u011f\u0131nt\u0131lar\u0131 \u00fczerine yap\u0131lan geni\u015f bir ara\u015ft\u0131rma yelpazesi, beynin farkl\u0131 durumlar ve ba\u011flamlar i\u00e7in uyarlanabilir stratejiler \u00fcretmek i\u00e7in birden fazla rekabet eden sistem i\u00e7erdi\u011fini g\u00f6stermektedir. [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":12280,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[748],"tags":[],"_links":{"self":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/12318"}],"collection":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/comments?post=12318"}],"version-history":[{"count":1,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/12318\/revisions"}],"predecessor-version":[{"id":12319,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/12318\/revisions\/12319"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/media\/12280"}],"wp:attachment":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/media?parent=12318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/categories?post=12318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/tags?post=12318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}