{"id":5258,"date":"2019-02-11T00:15:08","date_gmt":"2019-02-10T21:15:08","guid":{"rendered":"https:\/\/umram.bilkent.edu.tr\/?p=5258"},"modified":"2019-02-11T00:16:46","modified_gmt":"2019-02-10T21:16:46","slug":"umramda-seminer-dr-adema-ribic","status":"publish","type":"post","link":"https:\/\/umram.bilkent.edu.tr\/index.php\/tr\/2019\/02\/11\/umramda-seminer-dr-adema-ribic\/","title":{"rendered":"UMRAM\u2019da Seminer: Dr. Adema Ribic"},"content":{"rendered":"<section class=\"kc-elm kc-css-245865 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-748835 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-619669 kc_text_block\"><p>Dr. Adema Ribic, 31 Ocak 2019\u2019da, UMRAM\/Aysel Sabuncu Beyin Ara\u015ft\u0131rma Merkezi\u2019nde seminer verdi.\u00a0<\/p>\n<p><strong>Seminerin ba\u015fl\u0131\u011f\u0131:<\/strong> \u201cSynaptic Brakes on Neuroplasticity: Mechanism of Critical Period Closure in Visual Cortex\u201d.<\/p>\n<p><strong>Dr. Adema Ribic:<\/strong> \u015eu anda \u201cTufts University School of Medicine Sinirbilimi B\u00f6l\u00fcm\u00fc\u2019nde ara\u015ft\u0131rma g\u00f6revlisi olan Dr. Ribic\u2019in \u201cJournal of Neuroscience, Journal of Comparative Neurology, and Behavioral Brain Research\u201d gibi dergilerde yay\u0131nlar\u0131 bulunmaktad\u0131r. Doktoras\u0131n\u0131 Almanya\u2019daki G\u00f6ttingen \u00dcniversitesi Molek\u00fcler Biyoloji ve Sinirbilimi\u2019nde tamamlayan Ribic, post-doktoras\u0131n\u0131 Yale \u00dcniversitesi\u2019nde yapt\u0131.<\/p>\n<p><strong>Abstract:<\/strong> Connections between nerve cells in the brain, termed synapses, are formed using precise genetic programming and are remodeled with experience throughout lifetime. Synaptic remodeling is a highly regulated process, prominent in the developing, young brain when plasticity is high. Brain plasticity in mammals tapers off in adulthood, paralleling the maturation of inhibitory neurotransmission and a steady increase in the expression of nerve growth inhibitors. The goal of my research is to identify mechanisms that act at the synapse to direct synaptic remodeling and plasticity. My recent research demonstrated a key role of Synaptic Cell Adhesion Molecule 1 (SynCAM 1\/Cadm1) in maturation and plasticity of visual cortex. SynCAM 1 is a synaptic organizer that selectively controls development of subcortical, thalamic inputs onto Parvalbumin (PV+) inhibitory interneurons in the visual cortex. Loss of SynCAM 1 in PV+ interneurons retards the maturation of cortical inhibition and mice deficient in SynCAM 1 show increased visual plasticity at all ages, indicating that synaptic adhesion directs brain maturation. Even a brief loss of SynCAM 1 in PV+ interneurons upregulates plasticity in the adult brain, suggesting that plasticity is actively restricted through SynCAM 1 in adults. These results identify a synaptic locus for closure of developmental windows of plasticity, as well as a new synaptic factor that restricts adult plasticity.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":5259,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[445],"tags":[],"_links":{"self":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/5258"}],"collection":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/comments?post=5258"}],"version-history":[{"count":4,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/5258\/revisions"}],"predecessor-version":[{"id":5263,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/posts\/5258\/revisions\/5263"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/media\/5259"}],"wp:attachment":[{"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/media?parent=5258"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/categories?post=5258"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/umram.bilkent.edu.tr\/index.php\/wp-json\/wp\/v2\/tags?post=5258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}