Professor Kader Karli Oguz of UMRAM has received a notice of grant award from TUBITAK. Her project is entitled “ASSESSMENT OF RESTING-STATE FUNCTIONAL MAGNETIC RESONANCE IMAGING AND DIFFUSION TENSOR IMAGING FINDINGS AND CORRELATION WITH PROGNOSIS AFTER SURGERY IN REFRACTORY TEMPORAL LOBE EPILEPSY.” Her project’s abstract is as follows:
Although temporal lobe epilepsy (TLE), the most frequent type of focal epilepsy in adults has a variety of causes including ischemia, tumour and malformations, hippocampal sclerosis (HS) is the most common cause of TLE in surgical series. Usually it can be diagnosed reliably with Magnetic Resonance Imaging (MRI). In these patients, language and memory impairments correlating with hippocampal atrophy on MRI, also supported by histopathological studies occur depending on the affected hemisphere. Structural and functional abnormalities in HS extend beyond the hippocampi, even the limbic system. It is generally believed that language and memory impairments are associated with abnormalities in functional and white matter network in which hippocampi take part. However association of these interactions with clinical symptoms of the patients, extension of the differences from healthy individuals and relation with postoperative prognosis remain unclear.